Venetoclax Impurity 119 CAS CATO-C4X-2495119
| CAS No. | CATO-C4X-2495119 |
| Molecular Formula | C23H16F2N2O5 |
| Molecular Weight | 438.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Venetoclax Impurity 119 (CAS CATO-C4X-2495119, C23H16F2N2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Venetoclax Impurity 119 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 438.38 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H16F2N2O5 |
| Molecular Weight | 438.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Venetoclax Standards
- Venetoclax Impurity 71 (CAS CATO-C4X-249571)
- Venetoclax Impurity 92 (CAS CATO-C4X-249592)
- Venetoclax Impurity 76 (CAS CATO-C4X-249576)
- Venetoclax Impurity 93 (CAS CATO-C4X-249593)
- Venetoclax Impurity 151 (CAS CATO-C4X-2495151)
- Venetoclax Impurity 99 (CAS 64646-01-1)
- Venetoclax Impurity 17 (CAS CATO-C4X-249517)
- Venetoclax Impurity 55 (CAS 2514648-06-5)
Recommended Standards
- 20300-50-9 Odontoside (CAS 20300-50-9)
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- 3-(((4-Bromophenyl)thio)methyl)-4-phenyl-1-(p-tolyl)azetidin-2-one (CAS 866049-17-4)
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- Quetiapine Impurity 47 (CAS 14258-43-6)
- Methyl 3-[(E)-[(dimethylamino)methylidene]amino]-4-(4-fluorophenyl)thiophene-2-carboxylate (CAS 1334509-64-6)
- (3-Fluoro-benzyl)-(3-trifluoromethylsulfanyl-propyl)-amine (CAS 1208080-15-2)
- （See C4X-100319）Azithromycin EP Impurity A (See C4X-100319) (CAS CATO-C4X-10037)
- 1-Methyl-8-(trifluoromethyl)quinolin-4(1H)-one (CAS 1209284-64-9)
- 2-(Aminomethyl)-4-(difluoromethyl)-5-methylpyridine-3-acetic acid (CAS 1361783-84-7)
- (2R,3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-8-methylchroman-4-one (CAS 33788-39-5)
- Myelin Basic Protein (85-99) Peptide Antagonist (CAS 444305-16-2)
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