Venetoclax Impurity 76 CAS CATO-C4X-249576
| CAS No. | CATO-C4X-249576 |
| Molecular Formula | C25H22N4O4 |
| Molecular Weight | 442.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Venetoclax Impurity 76.
Venetoclax Impurity 76 (CAS CATO-C4X-249576) is a certified pharmaceutical impurity reference standard with the molecular formula C25H22N4O4 and a molecular weight of 442.47 g/mol.
Structurally, Venetoclax Impurity 76 (C25H22N4O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 17.0, corresponding to approximately 17 ring(s) or double-bond equivalent(s). With a molecular weight of 442.47 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H22N4O4 |
| Molecular Weight | 442.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 4 |
Related Venetoclax Standards
- Venetoclax Impurity 93 (CAS CATO-C4X-249593)
- Venetoclax Impurity 119 (CAS CATO-C4X-2495119)
- Venetoclax Impurity 71 (CAS CATO-C4X-249571)
- Venetoclax Impurity 92 (CAS CATO-C4X-249592)
- Venetoclax Impurity 99 (CAS 64646-01-1)
- Venetoclax Impurity 151 (CAS CATO-C4X-2495151)
- Venetoclax Impurity 17 (CAS CATO-C4X-249517)
- Venetoclax Impurity 55 (CAS 2514648-06-5)
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- Diclofenac Methyl Ester (Aceclofenac EP Impurity B) (CAS 15307-78-5)
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- 3-(Hydroxymethyl)cyclohexan-1-one (CAS 32916-58-8)
- N-(2-(Benzo[d]thiazol-2-yl)phenyl)-5-nitrofuran-2-carboxamide (CAS 380546-81-6)
- Ticagrelor Impurity 51 (CAS 1882095-51-3)
- 4-Amino-N-(2-chloro-5-fluorophenyl)benzenesulfonamide (CAS 1208077-12-6)
- Des-Phe22-Tirzepatide (CAS CATO-CPTD788951)
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