Venetoclax Impurity 71 CAS CATO-C4X-249571
| CAS No. | CATO-C4X-249571 |
| Molecular Formula | C23H16F2N2O5 |
| Molecular Weight | 438.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Venetoclax Impurity 71 (C23H16F2N2O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Venetoclax Impurity 71 (CAS CATO-C4X-249571, C23H16F2N2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Venetoclax Impurity 71 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H16F2N2O5 |
| Molecular Weight | 438.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Venetoclax Standards
- Venetoclax Impurity 119 (CAS CATO-C4X-2495119)
- Venetoclax Impurity 92 (CAS CATO-C4X-249592)
- Venetoclax Impurity 76 (CAS CATO-C4X-249576)
- Venetoclax Impurity 93 (CAS CATO-C4X-249593)
- Venetoclax Impurity 151 (CAS CATO-C4X-2495151)
- Venetoclax Impurity 99 (CAS 64646-01-1)
- Venetoclax Impurity 17 (CAS CATO-C4X-249517)
- Venetoclax Impurity 55 (CAS 2514648-06-5)
Recommended Standards
- 20300-50-9 Odontoside (CAS 20300-50-9)
- Letermovir Impurity 22 (CAS CATO-C4X-291522)
- 5-Methyl-N-(1,3-thiazol-2-yl)-3-[(2E)-3-{[4-(trifluoromethoxy)phenyl]amino}prop-2-enoyl]-1,2-oxazole-4-carboxamide (CAS 338794-77-7)
- TetraiSopropyl (2,5-dihydroxy-1,4-phenylene)bis(phosphonate) (CAS 1420992-09-1)
- Ceftibuten Impurity 15 (CAS CATO-C4X-189015)
- Sofosbuvir Impurity 123 (CAS 119804-96-5)
- Roxadustat Impurity 93 (CAS CATO-C4X-221393)
- Methyl 2-amino-3-(4-chlorophenyl)-2-methylpropanoate (CAS 64264-59-1)
- 3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(trifluoromethoxy)benzoic acid (CAS 2243515-63-9)
- 2-chloro-N-(2-methylbutan-2-yl)propanamide (CAS 42276-10-8)
- 5-((3-Methyl-4-nitrophenoxy)methyl)furan-2-carbohydrazide (CAS 832737-79-8)
- n-Ethyl-n-methyl-1h-pyrazole-4-sulfonamide (CAS 1178766-02-3)
- 1-(2-Methoxyethyl)-3-(5-(thiophen-2-yl)-1,3,4-oxadiazol-2-yl)urea (CAS 1207015-58-4)
- Semaglutide impurity 84 (CAS CATO-C4X-222684)
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