Venetoclax Impurity 143 CAS CATO-C4X-2495143
| CAS No. | CATO-C4X-2495143 |
| Molecular Formula | C19H27ClN2O |
| Molecular Weight | 334.88 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Venetoclax Impurity 143 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Venetoclax Impurity 143 (CAS CATO-C4X-2495143), a pharmacopoeial impurity reference standard (molecular formula C19H27ClN2O, MW 334.88 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Venetoclax Impurity 143 (C19H27ClN2O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 334.88 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C19H27ClN2O |
| Molecular Weight | 334.88 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Venetoclax Standards
- Venetoclax Impurity 66 (CAS CATO-C4X-249566)
- Venetoclax Impurity 139 (CAS CATO-C4X-2495139)
- Venetoclax Impurity 53 (CAS CATO-C4X-249553)
- Venetoclax Impurity 72 (CAS 2007920-25-2)
- Venetoclax Impurity 78 (CAS CATO-C4X-249578)
- Venetoclax Impurity 14 (CAS CATO-C4X-249514)
- Venetoclax Impurity 79 (CAS CATO-C4X-249579)
- Venetoclax Impurity 52 (CAS CATO-C4X-249552)
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