Venetoclax Impurity 72 CAS 2007920-25-2
| CAS No. | 2007920-25-2 |
| Molecular Formula | C18H17FN2O3 |
| Molecular Weight | 328.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Venetoclax Impurity 72 (CAS 2007920-25-2, C18H17FN2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Venetoclax Impurity 72 (C18H17FN2O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 328.34 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H17FN2O3 |
| Molecular Weight | 328.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Venetoclax Standards
- Venetoclax Impurity 78 (CAS CATO-C4X-249578)
- Venetoclax Impurity 53 (CAS CATO-C4X-249553)
- Venetoclax Impurity 139 (CAS CATO-C4X-2495139)
- Venetoclax Impurity 143 (CAS CATO-C4X-2495143)
- Venetoclax Impurity 66 (CAS CATO-C4X-249566)
- Venetoclax Impurity 138 (CAS CATO-C4X-2495138)
- Venetoclax Impurity 136 (CAS CATO-C4X-2495136)
- Venetoclax Impurity 1 (CAS 1228779-96-1)
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