Venetoclax Impurity 48 CAS CATO-C4X-249548
| CAS No. | CATO-C4X-249548 |
| Molecular Formula | C52H61ClN6O3 |
| Molecular Weight | 853.53 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Venetoclax Impurity 48 (C52H61ClN6O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Venetoclax Impurity 48 (CAS CATO-C4X-249548) is a certified pharmaceutical impurity reference standard with the molecular formula C52H61ClN6O3 and a molecular weight of 853.53 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Venetoclax Impurity 48 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C52H61ClN6O3 |
| Molecular Weight | 853.53 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 25.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Venetoclax Standards
- Venetoclax Impurity 33 (CAS CATO-C4X-249533)
- Venetoclax Impurity 64 (CAS CATO-C4X-249564)
- Venetoclax Impurity 62 (CAS CATO-C4X-249562)
- Venetoclax (CAS 1257044-40-8)
- Venetoclax Impurity 45 (CAS CATO-C4X-249545)
- Venetoclax Impurity 42 (CAS CATO-C4X-249542)
- Venetoclax Impurity 100 (CAS CATO-C4X-2495100)
- Venetoclax Impurity 121 (CAS CATO-C4X-2495121)
Recommended Standards
- Menaquinone 10 (CAS 523-40-0)
- S-Malonyl-CoA (CAS 524-14-1)
- Teneligliptin impurity 34 (CAS CATO-C4X-176034)
- 3-Hydroxybutyrate Coenzyme A (CAS 2871-66-1)
- Moxifloxacin Impurity 118 (CAS 1395056-42-4)
- Tinidazole Impurity 23 (CAS CATO-C4X-193023)
- Pivmecillinam Impurity 15 (CAS CATO-C4X-232315)
- Chloro-Sibutramine (CAS 766462-77-5)
- H-Trp(Boc)-OH (CAS 2074728-72-4)
- 6-Amino-1-(4-methoxyphenyl)-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-4-one (CAS 180028-93-7)
- 4-Bromonaphthalene-1-carboxamide (CAS 112750-58-0)
- Alpha-HCH (CAS 319-84-6)
- (2-Chloro-4-ethylpyrimidin-5-yl)boronic acid (CAS 2225177-41-1)
- Semaglutide impurity 201 (CAS CATO-C4X-2226201)
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