Venetoclax Impurity 100 CAS CATO-C4X-2495100
| CAS No. | CATO-C4X-2495100 |
| Molecular Formula | C49H46ClN5O6 |
| Molecular Weight | 836.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Venetoclax Impurity 100 (CAS CATO-C4X-2495100), a pharmacopoeial impurity reference standard (molecular formula C49H46ClN5O6, MW 836.37 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Venetoclax Impurity 100 is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 836.37 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C49H46ClN5O6 |
| Molecular Weight | 836.37 g/mol |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 29.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Venetoclax Standards
- Venetoclax Impurity 121 (CAS CATO-C4X-2495121)
- Venetoclax Impurity 42 (CAS CATO-C4X-249542)
- Venetoclax Impurity 8 (CAS 2573767-91-4)
- Venetoclax Impurity 64 (CAS CATO-C4X-249564)
- Venetoclax Impurity 134 (CAS CATO-C4X-2495134)
- Venetoclax Impurity 112 (CAS CATO-C4X-2495112)
- Venetoclax Impurity 33 (CAS CATO-C4X-249533)
- Venetoclax Impurity 48 (CAS CATO-C4X-249548)
Recommended Standards
- 1,1,2,2-Tetrakis(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethene (CAS 1660996-72-4)
- 2-(Bis(3,5-di-tert-butylphenyl)phosphino)-N-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)benzamide (CAS 2389028-68-4)
- 5',5'''-Diadenosine tetraphosphate (CAS 5542-28-9)
- 22:6 PE (CAS 123284-81-1)
- Noradrenaline Hydrochloride EP Impurity B (CAS 5090-29-9)
- Terbutaline Impurity 34 (CAS 28924-18-7)
- Raloxifene Impurity N65 (CAS 63675-73-0)
- 1-Oxa-8-azaspiro[4.5]decane (CAS 176-92-1)
- 2-Amino-3-(2-chloro-3,6-difluorophenyl)propanoic acid (CAS 1259981-12-8)
- 4-Bromo-2-(pyrrolidin-1-yl)benzonitrile (CAS 1359821-89-8)
- 4-O-Methylochnaflavone (CAS 49619-87-6)
- Loxoprofen impurity 85 (CAS 335096-46-3)
- 1-(Isopropylthio)-3-oxocyclobutane-1-carboxylic acid (CAS 1494424-54-2)
- Fas C- Terminal Tripeptide (CAS 189109-90-8)
Why CATO?
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