Tucatinib Impurity 48 CAS CATO-C4X-260548
| CAS No. | CATO-C4X-260548 |
| Molecular Formula | C9H9N3O2 |
| Molecular Weight | 191.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Tucatinib Impurity 48 (CAS CATO-C4X-260548, C9H9N3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Tucatinib Impurity 48 (C9H9N3O2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Tucatinib Impurity 48 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H9N3O2 |
| Molecular Weight | 191.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
Related Tucatinib Standards
- Tucatinib Impurity 66 (CAS CATO-C4X-260566)
- Tucatinib Impurity 23 (CAS 920966-13-8)
- Tucatinib Impurity 22 (CAS 920966-03-6)
- Tucatinib Impurity 6 (CAS CATO-C4X-26056)
- Tucatinib Impurity 29 (CAS CATO-C4X-260529)
- Tucatinib Impurity 42 (CAS CATO-C4X-260542)
- Tucatinib Impurity 43 (CAS CATO-C4X-260543)
- Tucatinib Impurity 41 (CAS CATO-C4X-260541)
Recommended Standards
- Pazopanib Impurity 22 (CAS 444731-73-1)
- 3-(4-Azidophenyl)propionic acid (CAS 103489-31-2)
- Albendazole EP Impurity E (CAS 10605-21-7)
- 4-amino-2-fluoro-5-methoxy-benzoic acid (CAS 1001346-91-3)
- Cefprozil Impurity 57 (CAS CATO-C4X-149257)
- Sunitinib Impurity 17 (CAS CATO-C4X-133317)
- Benserazide impurity 52 (CAS CATO-C4X-142752)
- 4-((Methylamino)methyl)benzene-1,2-diol (CAS 125789-62-0)
- 4-(Diethylamino)-3-iodobenzoic acid (CAS 1131588-22-1)
- (4AS,5aS)-1-(pyrazin-2-yl)-4,4a,5,5a-tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2-c]pyrazole-3-carboxylic acid (CAS 1268882-99-0)
- (S)-Methyl 5-bromo-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (CAS 2381362-37-2)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-4-((4-pentylphenyl)sulfonyl)-1,4-diazepane (CAS 646456-06-6)
- 3-(4-bromobenzyl)-2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine (CAS 154553-72-7)
- Semaglutide impurity 270 (CAS CATO-C4X-2226270)
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