Apalutamide Impurity 111 CAS CATO-C4X-2749111
| CAS No. | CATO-C4X-2749111 |
| Molecular Formula | C21H21F2N3O4 |
| Molecular Weight | 417.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Apalutamide Impurity 111 (CAS CATO-C4X-2749111, C21H21F2N3O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C21H21F2N3O4, Apalutamide Impurity 111 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 417.41 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Apalutamide Impurity 111 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H21F2N3O4 |
| Molecular Weight | 417.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Apalutamide Standards
- Apalutamide Impurity 110 (CAS CATO-C4X-2749110)
- Apalutamide Impurity 36 (CAS CATO-C4X-274936)
- Apalutamide Impurity 100 (CAS CATO-C4X-2749100)
- Apalutamide Impurity 65 (CAS CATO-C4X-274965)
- Apalutamide Impurity 67 (CAS CATO-C4X-274967)
- Apalutamide Impurity 30 (CAS CATO-C4X-274930)
- Apalutamide Impurity 23 (CAS CATO-C4X-274923)
- Apalutamide Impurity 16 (CAS 1950587-20-8)
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