Apalutamide Impurity 65 CAS CATO-C4X-274965
| CAS No. | CATO-C4X-274965 |
| Molecular Formula | C16H8F6N6O |
| Molecular Weight | 414.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Apalutamide Impurity 65.
CATO supplies Apalutamide Impurity 65 (CAS CATO-C4X-274965), a pharmacopoeial impurity reference standard (molecular formula C16H8F6N6O, MW 414.26 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Apalutamide Impurity 65 (C16H8F6N6O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 414.26 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H8F6N6O |
| Molecular Weight | 414.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Related Apalutamide Standards
- Apalutamide Impurity 100 (CAS CATO-C4X-2749100)
- Apalutamide Impurity 67 (CAS CATO-C4X-274967)
- Apalutamide Impurity 36 (CAS CATO-C4X-274936)
- Apalutamide Impurity 110 (CAS CATO-C4X-2749110)
- Apalutamide Impurity 111 (CAS CATO-C4X-2749111)
- Apalutamide Impurity 30 (CAS CATO-C4X-274930)
- Apalutamide Impurity 23 (CAS CATO-C4X-274923)
- Apalutamide Impurity 74 (CAS CATO-C4X-274974)
Recommended Standards
- Dotinurad Impurity 237 (CAS CATO-C4X-2494237)
- 4-Bromo-N-(9-oxo-9H-fluoren-1-yl)benzene-1-sulfonamide (CAS 866155-11-5)
- 1-{6-[(2,4-dichlorophenyl)methyl]pyridazin-3-yl}-4-(4-fluorophenyl)-1H-pyrazol-5-amine (CAS 321385-80-2)
- N-((4-bromophenyl)sulfonyl)-N-(4-ethoxyphenyl)glycine (CAS 401602-95-7)
- Tadalafil Impurity 174 (CAS CATO-C4X-1087174)
- Labetalol Impurity 66 (CAS CATO-C4X-246666)
- Oclacitinib Impurity 30 (CAS CATO-C4X-301830)
- 5-Nitro-2-styrylpyrimidine (CAS 54246-65-0)
- 4-Bromo-N,N-di-p-tolylaniline (CAS 58047-42-0)
- Tert-butyl 4-(4-(5-(p-tolyl)-1,2,4-oxadiazol-3-yl)phenyl)piperazine-1-carboxylate (CAS 866018-80-6)
- Methyl 2-(Bromomethyl)-5-methoxybenzoate (CAS 788081-99-2)
- (E)-1-(7-(2-(dimethylamino)vinyl)-2-(methylthio)-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)ethan-1-one (CAS 1306753-65-0)
- 2-Amino-N-(4-(methylthio)benzyl)acetamide (CAS 1353965-18-0)
- Insulin Degludec Impurity 28 (CAS CATO-C4X-215728)
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