Apalutamide Impurity 110 CAS CATO-C4X-2749110
| CAS No. | CATO-C4X-2749110 |
| Molecular Formula | C20H18F3N5O2 |
| Molecular Weight | 417.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Apalutamide Impurity 110 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Apalutamide Impurity 110 (CAS CATO-C4X-2749110, C20H18F3N5O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C20H18F3N5O2, Apalutamide Impurity 110 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 417.38 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H18F3N5O2 |
| Molecular Weight | 417.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Apalutamide Standards
- Apalutamide Impurity 111 (CAS CATO-C4X-2749111)
- Apalutamide Impurity 36 (CAS CATO-C4X-274936)
- Apalutamide Impurity 100 (CAS CATO-C4X-2749100)
- Apalutamide Impurity 65 (CAS CATO-C4X-274965)
- Apalutamide Impurity 67 (CAS CATO-C4X-274967)
- Apalutamide Impurity 30 (CAS CATO-C4X-274930)
- Apalutamide Impurity 23 (CAS CATO-C4X-274923)
- Apalutamide Impurity 16 (CAS 1950587-20-8)
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