Coclaurine Impurity 16 CAS CATO-C4X-27516
| CAS No. | CATO-C4X-27516 |
| Molecular Formula | C20H25NO4 |
| Molecular Weight | 343.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Coclaurine Impurity 16 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Coclaurine Impurity 16 (CAS CATO-C4X-27516, C20H25NO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, Coclaurine Impurity 16 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 343.42 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Coclaurine Impurity 16 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H25NO4 |
| Molecular Weight | 343.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Coclaurine Standards
- Coclaurine Impurity 1 (CAS 4078-65-3)
- Coclaurine Impurity 6 (CAS 3472-22-8)
- Coclaurine Impurity 113 (CAS 2158198-78-6(TFA Salt))
- Coclaurine Impurity 114 (CAS 31804-74-7)
- Coclaurine Impurity 115 (CAS CATO-C4X-275115)
- Coclaurine Impurity 15 (CAS CATO-C4X-27515)
- (+)-Coclaurine (CAS 2196-60-3)
- Coclaurine (CAS 486-39-5)
Recommended Standards
- Labetalol Impurity 53 (CAS 802620-01-5)
- Sarpogrelate Impurity 10 (CAS CATO-C4X-291310)
- Dienogest Impurity 15 (CAS CATO-C4X-229515)
- R-Tetrahydropapaverine N-acetyl-L-leucinate (CAS 50896-90-7)
- Vardenafil Impurity 63 (CAS CATO-C4X-101763)
- Fluvastatin Impurity N5 (CAS 920275-09-8)
- Tetrabenazine Impurity 15 (CAS 1256550-62-5)
- 2-(3-fluoropyrrolidin-3-yl)acetic acid (CAS 1781297-14-0)
- (2-Chloro-5-fluoropyrimidin-4-yl)-(4-trifluoromethylphenyl)amine (CAS 575473-53-9)
- (R)-3-Amino-1,1,1-trifluoropropan-2-ol hydrochloride (CAS 1305712-58-6)
- Loxoprofen Impurity 139 (CAS CATO-C4X-1488139)
- 4-(Benzo[c][1,2,5]oxadiazol-4-ylamino)butanoic acid (CAS 89160-46-3)
- 1-(2,2-Difluoroethyl)-4-iodo-3-(isopropoxymethyl)-1H-pyrazole (CAS 1856031-70-3)
- Proinsulin C-Peptide (55-89) (human) (CAS 11097-48-6)
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