Sacubitril impurity 43 CAS CATO-C4X-280943
| CAS No. | CATO-C4X-280943 |
| Molecular Formula | 2*C24H28NO5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Sacubitril impurity 43.
As a process- or degradation-related impurity, Sacubitril impurity 43 (CAS CATO-C4X-280943, C24H28NO5Ca) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Sacubitril impurity 43 (C24H28NO5Ca) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | 2*C24H28NO5 Ca |
| Molecular Weight | 450.57 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Sacubitril Standards
- Sacubitril impurity 41 (CAS 1038924-61-6)
- Sacubitril Impurity 5 (CAS 1038925-00-6)
- Sacubitril Lactam (CAS 1038925-22-2)
- Sacubitril impurity 50 (CAS 1039307-95-3（free base）)
- Sacubitril Sodium Salt (CAS 149690-05-1)
- Sacubitril impurity 54 (CAS 149709-63-7)
- Sacubitril Impurity 55 (CAS 149818-98-4)
- Sacubitril impurity 18 (CAS 1810778-75-6)
Recommended Standards
- Tirofiban Impurity 62 (CAS CATO-C4X-125462)
- Pravastatin EP Impurity B Sodium Salt (CAS 722504-46-3)
- Eplerenone Impurity 36 (CAS CATO-C4X-163036)
- 1-(2-Amino-2-oxoethyl)azetidine-3-carboxylic acid (CAS 1343639-12-2)
- 3-Methylisothiazolo[5,4-b]quinoline (CAS 548930-76-3)
- 7-Fluoro-3-(methoxymethoxy)-8-((triisopropylsilyl)ethynyl)naphthalen-1-ol (CAS 2621932-35-0)
- 3-(4-(Trifluoromethyl)phenyl)bicyclo[1.1.1]Pentane-1-carboxylic acid (CAS 2077118-04-6)
- 5-(3,4-Dimethoxyphenyl)-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine (CAS 893615-43-5)
- 1-(3-Nitrophenyl)-3-((3-nitrophenyl)amino)propan-1-one (CAS 340165-90-4)
- [y-Glu15]-Semaglutide Impurity 134 (CAS CATO-C4X-2226134)
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