Sacubitril impurity 9 CAS CATO-C4X-28099
| CAS No. | CATO-C4X-28099 |
| Molecular Formula | C18H18N2O2 |
| Molecular Weight | 294.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Sacubitril impurity 9 (CAS CATO-C4X-28099, C18H18N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Sacubitril impurity 9 (C18H18N2O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C18H18N2O2 |
| Molecular Weight | 294.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 2 |
Related Sacubitril Standards
- Sacubitril Impurity 57 (CAS 556828-95-6)
- Sacubitril Impurity 25 (CAS CATO-C4X-280925)
- Sacubitril Impurity 38 (CAS CATO-C4X-280938)
- Sacubitril impurity 16 (CAS CATO-C4X-280916)
- Sacubitril Lactam (CAS 1038925-22-2)
- Sacubitril Impurity 5 (CAS 1038925-00-6)
- Sacubitril impurity 15 (CAS CATO-C4X-280915)
- Sacubitril impurity 11 (CAS 182192-86-5)
Recommended Standards
- Solriamfetol Impurity 24 (CAS CATO-C4X-256324)
- Difelikefalin Impurity 46 (CAS 1021171-64-1)
- Solriamfetol Impurity 22 (CAS CATO-C4X-256322)
- Triphenylphosphine Sulfide (CAS 3878-45-3)
- Naltrexone impurity 45 (CAS CATO-C4X-147545)
- Tigecycline Impurity 30 (CAS CATO-C4X-186030)
- Cariprazine Impurity 20 (CAS CATO-C4X-240820)
- 1,1-Dichloroethene (CAS 75-35-4)
- N-(4-Chloro-2-methoxy-5-methylphenyl)pivalamide (CAS 449170-24-5)
- (E)-3-(4-(allyloxy)-3,5-dichlorophenyl)acrylic acid (CAS 937599-17-2)
- Methyl 3-(2-{[2-(4-methoxybenzenesulfonamido)phenyl]sulfanyl}acetamido)thiophene-2-carboxylate (CAS 477869-09-3)
- (S)-tert-Butyl ((1-(1-methyl-4-nitro-1H-pyrazol-5-yl)piperidin-3-yl)methyl)carbamate (CAS 1363408-44-9)
- Ethyl 8-oxotridecanoate (CAS 898776-48-2)
- Semaglutide Impurity 8 (CAS CATO-C4X-22268)
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