Nefopam Impurity 37 CAS CATO-C4X-283737
| CAS No. | CATO-C4X-283737 |
| Molecular Formula | C7H4ClN3O |
| Molecular Weight | 181.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Nefopam Impurity 37 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 181.58 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Nefopam Impurity 37 (CAS CATO-C4X-283737, C7H4ClN3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Nefopam Impurity 37 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H4ClN3O |
| Molecular Weight | 181.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Nefopam Standards
- Nefopam Impurity 38 (CAS CATO-C4X-283738)
- Nefopam Impurity 8 (CAS 918306-38-4)
- Nefopam Impurity 11 (CAS CATO-C4X-283711)
- Nefopam Impurity 1 (CAS CATO-C4X-28381)
- Nefopam Impurity 4 (CAS 32557-55-4)
- Nefopam impurity 22 (CAS CATO-C4X-283722)
- Nefopam impurity 23 (CAS CATO-C4X-283723)
- Nefopam Impurity 7 (CAS 22103-85-1)
Recommended Standards
- 5-Chloroisatin (CAS 17630-76-1)
- 7-Chloro-4-fluoroquinoline (CAS 103526-68-7)
- Pyrazolo[1,5-a]pyrimidine-3-carbonyl chloride (CAS 937602-40-9)
- 3-Chloro-6-fluoroisoquinoline, 97% (CAS 1041423-28-2)
- Tofacitinib Impurity 31 (CAS 923036-25-3)
- Folic acid impurity 58 (CAS CATO-C4X-139558)
- Sodium Fusidate EP Impurity A (CAS 80445-74-5)
- n-(2,2-Dimethoxyethyl)-3,4-dihydro-2h-pyrrol-5-amine (CAS 1211463-67-0)
- 1-(3-Ethynylphenyl)-N-methylmethanamine (CAS 1854001-74-3)
- 2-Butoxy-5-nitropyridine (CAS 6627-95-8)
- Bis[2-(amino-κN)ethanesulfonato-κO]iron (CAS 509086-19-5)
- 3-Methoxypropylisothiocyanate (CAS 28115-86-8)
- Levetiracetam EP Impurity E (CAS 3886-69-9)
- Liraglutide Impurity 10 TFA Salt (CAS CATO-C4X-199210)
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