Tafamidis Impurity 5 CAS CATO-C4X-28775
| CAS No. | CATO-C4X-28775 |
| Molecular Formula | C17H13Cl2NO3 |
| Molecular Weight | 350.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Tafamidis Impurity 5 (CAS CATO-C4X-28775), a pharmacopoeial impurity reference standard (molecular formula C17H13Cl2NO3, MW 350.20 g/mol) used for the identification and quantification of trace impurities in APIs.
Tafamidis Impurity 5 (C17H13Cl2NO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C17H13Cl2NO3 |
| Molecular Weight | 350.20 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Tafamidis Standards
- Tafamidis Impurity 7 (CAS CATO-C4X-28777)
- Tafamidis Impurity 13 (CAS CATO-C4X-287713)
- Tafamidis Impurity 1 (CAS 1184581-58-5)
- Tafamidis Impurity 3 (CAS 1183404-30-9)
- Tafamidis Impurity 9 (CAS 1395964-06-3)
- Tafamidis (CAS 594839-88-0)
- Tafamidis impurity 10 (CAS CATO-C4X-287710)
- Tafamidis Impurity 6 (CAS 1507158-86-2)
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