Vericiguat impurity 50 CAS CATO-C4X-289650
| CAS No. | CATO-C4X-289650 |
| Molecular Formula | C21H18F2N8O4 |
| Molecular Weight | 484.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Vericiguat impurity 50.
Vericiguat impurity 50 (CAS CATO-C4X-289650) is a certified pharmaceutical impurity reference standard with the molecular formula C21H18F2N8O4 and a molecular weight of 484.42 g/mol.
Vericiguat impurity 50 (C21H18F2N8O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H18F2N8O4 |
| Molecular Weight | 484.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Vericiguat Standards
- Vericiguat impurity 55 (CAS CATO-C4X-289655)
- Vericiguat Impurity 6 (CAS CATO-C4X-28966)
- Vericiguat Impurity 68 (CAS CATO-C4X-289668)
- Vericiguat Impurity 33 (CAS CATO-C4X-289633)
- Vericiguat Impurity 34 (CAS CATO-C4X-289634)
- Vericiguat Impurity 11 (CAS 1350653-29-0)
- Vericiguat Impurity 23 (CAS CATO-C4X-289623)
- Vericiguat Impurity 28 (CAS CATO-C4X-289628)
Recommended Standards
- Methyl 4-{[(5-{[(2,6-dichlorophenyl)methanesulfinyl]methyl}-4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}benzoate (CAS 344271-91-6)
- Methyl 4-(((5-(((2,4-dichlorobenzyl)sulfinyl)methyl)-4-methyl-4H-1,2,4-triazol-3-yl)thio)methyl)benzoate (CAS 344272-17-9)
- Tris(4-trifluorotolyl)phosphine (CAS 13406-29-6)
- Vilanterol Impurity 86 (CAS 2514696-13-8)
- Iopromide impurity 13 (CAS CATO-C4X-183213)
- Melatonin Impurity 27 (CAS 188397-02-6)
- Pentoxyverine Impurity 14 (CAS CATO-C4X-227014)
- 4-(Methylamino)pyrimidine-5-carbonitrile (CAS 16357-70-3)
- Topiroxostat Impurity 40 (CAS 4923-06-2)
- Phenolphthaleindiphosphatecalciumsalt (CAS 94465-66-4)
- 5-Amino-7-methoxy-8-(3-morpholinopropoxy)-2,3-dihydroimidazo[1,2-c]quinazoline (CAS 1032570-74-3)
- 1-Hydroxyisoquinoline-5-carbonitrile (CAS 90947-07-2)
- 4-Bromo-3-(difluoromethoxy)thiophene-2-carboxylic acid (CAS 1774902-95-2)
- Peptide 441 (CAS CATO-CPTD788441)
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