Vericiguat Impurity 68 CAS CATO-C4X-289668
| CAS No. | CATO-C4X-289668 |
| Molecular Formula | C21H18F2N8O4 |
| Molecular Weight | 484.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Vericiguat Impurity 68 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Vericiguat Impurity 68 (CAS CATO-C4X-289668, C21H18F2N8O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Vericiguat Impurity 68 (C21H18F2N8O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Vericiguat Impurity 68 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H18F2N8O4 |
| Molecular Weight | 484.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Vericiguat Standards
- Vericiguat impurity 50 (CAS CATO-C4X-289650)
- Vericiguat impurity 55 (CAS CATO-C4X-289655)
- Vericiguat Impurity 6 (CAS CATO-C4X-28966)
- Vericiguat Impurity 33 (CAS CATO-C4X-289633)
- Vericiguat Impurity 34 (CAS CATO-C4X-289634)
- Vericiguat Impurity 11 (CAS 1350653-29-0)
- Vericiguat Impurity 23 (CAS CATO-C4X-289623)
- Vericiguat Impurity 28 (CAS CATO-C4X-289628)
Recommended Standards
- Resveratrol-3-Sulfate-4′-Glucuronide (CAS 1028964-64-8)
- 2-(4-((5-Bromothiophen-2-yl)sulfonyl)piperazin-1-yl)-1-(3,4-dihydroquinolin-1(2H)-yl)ethan-1-one (CAS 870763-68-1)
- 5-(6-((4-Bromobenzyl)thio)pyridazin-3-yl)-2-(4-methoxyphenyl)-4-methylthiazole (CAS 954661-79-1)
- Methyl 4-{[(5-{[(2,6-dichlorophenyl)methanesulfinyl]methyl}-4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}benzoate (CAS 344271-91-6)
- Atrasentan Impurity 155 (CAS 1073831-62-5)
- Triacetic Acid Impurity 3 (CAS 862542-34-5)
- Dapagliflozin Impurity 42 (CAS CATO-C4X-113842)
- 2-(((4-Bromo-2-ethylphenyl)amino)methyl)isoindoline-1,3-dione (CAS 1241674-55-4)
- N-(2-Hydrazono-4-(4-methoxyphenyl)pyrimidin-1(2H)-yl)benzamide (CAS 127252-15-7)
- Bis(4-(tert-butyl)phenyl)iodoniumchloride (CAS 5421-53-4)
- 4-(3-Bromopropoxy)-3-methoxybenzonitrile (CAS 3244-23-3)
- 6-Bromopyrrolo[1,2-d][1,2,4]triazin-1(2H)-one (CAS 50269-93-7)
- N-(4-fluorophenyl)carbonohydrazonoyl dicyanide (CAS 94853-74-4)
- Des-Gly29,30-Tirzepatide (CAS CATO-CPTD788944)
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