Resmetirom Impurity 43 CAS CATO-C4X-291243
| CAS No. | CATO-C4X-291243 |
| Molecular Formula | C10H8Cl3N3O |
| Molecular Weight | 292.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Resmetirom Impurity 43 (CAS CATO-C4X-291243, C10H8Cl3N3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Resmetirom Impurity 43 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 292.55 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Resmetirom Impurity 43 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H8Cl3N3O |
| Molecular Weight | 292.55 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Resmetirom Standards
- Resmetirom Impurity 8 (CAS 1581304-46-2)
- Resmetirom Impurity 62 (CAS CATO-C4X-291262)
- Resmetirom impurity 66 (CAS CATO-C4X-291266)
- Resmetirom impurity 67 (CAS CATO-C4X-291267)
- Resmetirom Impurity 9 (CAS CATO-C4X-29129)
- Resmetirom impurity 121 (CAS CATO-C4X-2912121)
- Resmetirom Impurity 22 (CAS 125001-18-5)
- Resmetirom impurity 124 (CAS CATO-C4X-2912124)
Recommended Standards
- 8-(((2-Chlorophenyl)(vinyl)boraneyl)oxy)quinoline (CAS 871816-96-5)
- 2-(2-Bromo-4-chlorophenoxy)-N,N-dimethylacetamide (CAS 1030438-47-1)
- 4-tert-Butylbenzylzinc bromide 0.5 M in Tetrahydrofuran (CAS 737797-48-7)
- 2-Bromo-9-chloroacridine (CAS 10352-10-0)
- Vardenafil Impurity 31 (CAS CATO-C4X-101731)
- Tolterodine Impurity 13 (CAS 88407-29-8)
- Mivacurium chloride Impurity 54 (CAS CATO-C4X-137554)
- 7-Nitro-2,3-dihydrobenzofuran-3-amine (CAS 1273665-67-0)
- 1-(1-Ethyl-1H-pyrazol-3-yl)-N-((1-ethyl-3-methyl-1H-pyrazol-4-yl)methyl)methanamine hydrochloride (CAS 1856050-70-8)
- 1-Butyl-1-methylpyrrolidinium Hexafluorophosphate (CAS 330671-29-9)
- 2-(Piperazin-1-yl)-1-(m-tolyl)ethan-1-ol (CAS 897552-62-4)
- 2-(Trifluoromethyl)thiazole-4-carboxamide (CAS 1180526-74-2)
- 1-(4-methylbenzyl)-1H-indol-3-yl cyanide (CAS 1226171-02-3)
- Tirzepatide Impurity 44 (CAS CATO-C4X-324044)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com