Resmetirom impurity 112 CAS CATO-C4X-2912112
| CAS No. | CATO-C4X-2912112 |
| Molecular Formula | C19H15Cl4N3O3 |
| Molecular Weight | 475.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Resmetirom impurity 112 (CAS CATO-C4X-2912112), a pharmacopoeial impurity reference standard (molecular formula C19H15Cl4N3O3, MW 475.15 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Resmetirom impurity 112 (C19H15Cl4N3O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 475.15 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO manufactures Resmetirom impurity 112 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C19H15Cl4N3O3 |
| Molecular Weight | 475.15 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Resmetirom Standards
- Resmetirom impurity 56 (CAS 3033842-98-4)
- Resmetirom Impurity 31 (CAS CATO-C4X-291231)
- Resmetirom impurity 130 (CAS CATO-C4X-2912130)
- Resmetirom impurity 139 (CAS 1581304-53-1)
- Resmetirom impurity 16 (CAS 920509-33-7)
- Resmetirom Impurity 34 (CAS CATO-C4X-291234)
- Resmetirom Impurity 42 (CAS CATO-C4X-291242)
- Resmetirom impurity 84 (CAS CATO-C4X-291284)
Recommended Standards
- N-(2-(5-Bromo-1H-indol-3-yl)ethyl)-2-iodothiophene-3-carboxamide (CAS 920506-29-2)
- 3-(2,4-Dichlorophenyl)-N-(3,4-dichlorophenyl)-[1,2,4]triazolo[4,3-c]quinazolin-5-amine (CAS 400075-14-1)
- Cyclopentenylcytosine-5-triphosphate (CAS 118045-71-9)
- Sorafenib Impurity 59 (CAS CATO-C4X-112459)
- Alogliptin Impurity 52 (CAS CATO-C4X-109952)
- Vonoprazan Impurity 49 (CAS CATO-C4X-1020249)
- Minocycline Impurity 70 (CAS CATO-C4X-169970)
- 2-Methylnicotinoyl chloride (CAS 169229-06-5)
- 2-(3-Methoxyphenyl)quinoline-8-carboxamide (CAS 655222-48-3)
- 1-Bromo-2-((2-ethylhexyl)oxy)cyclopentane (CAS 1339569-77-5)
- 5'-(4-Amino-3,5-diethylphenyl)-3,3'',5,5''-tetraethyl-[1,1':3',1''-terphenyl]-4,4''-diamine (CAS 2250216-97-6)
- 2-(5-Methoxy-1h-pyrrolo[3,2-b]pyridin-3-yl)ethanamine (CAS 1171071-94-5)
- Apalutamide Impurity 98 (CAS CATO-C4X-274998)
- Acetyl Tetrapeptide- 15 (CAS 928007-64-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com