Letermovir impurity 137 CAS CATO-C4X-2915137
| CAS No. | CATO-C4X-2915137 |
| Molecular Formula | C22H24FN3O4 |
| Molecular Weight | 413.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 413.44 g/mol gives Letermovir impurity 137 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Letermovir impurity 137 (CAS CATO-C4X-2915137), a pharmacopoeial impurity reference standard (molecular formula C22H24FN3O4, MW 413.44 g/mol) used for the identification and quantification of trace impurities in APIs.
Letermovir impurity 137 (C22H24FN3O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H24FN3O4 |
| Molecular Weight | 413.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Letermovir Standards
- Letermovir Impurity 58 (CAS CATO-C4X-291558)
- Letermovir Impurity 132 (CAS CATO-C4X-2915132)
- Letermovir Impurity 71 (CAS CATO-C4X-291571)
- Letermovir Impurity 75 (CAS CATO-C4X-291575)
- Letermovir Impurity 83 (CAS CATO-C4X-291583)
- Letermovir Impurity 85 (CAS CATO-C4X-291585)
- Letermovir Impurity 90 (CAS CATO-C4X-291590)
- Letermovir Impurity 92 (CAS CATO-C4X-291592)
Recommended Standards
- Piperidine Impurity 1 (CAS 1463453-46-4)
- 5-(4-Fluorobenzyl)-8-methoxy-3-(4-methoxyphenyl)-5H-pyrazolo[4,3-c]quinoline (CAS 866347-48-0)
- N,N-Dimethyl-4-(3-(3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl)azetidine-1-carbonyl)benzenesulfonamide (CAS 1251558-67-4)
- 5-(2-Fluorobenzyl)-8-methoxy-3-(4-methoxyphenyl)-5H-pyrazolo[4,3-c]quinoline (CAS 866349-45-3)
- Sitagliptin Impurity 63 (CAS 1864680-46-5)
- Carfilzomib Impurity 37 (Trifluoroacetic Acid) (CAS 868539-99-5)
- Norepinephrine Impurity 122 (CAS CATO-C4X-1514122)
- 4-(3,4-Dihydroisoquinolin-2(1H)-yl)-4-oxobutanoic acid (CAS 366454-59-3)
- 2-(Difluoromethoxy)-5-methoxyphenol (CAS 1261825-52-8)
- Upadacitinib Impurity 33 (CAS 2650489-66-8)
- 1-Isopropyl-1H-1,2,3-triazole-5-carboxylic acid (CAS 1198437-54-5)
- 5-Cyclopropoxy-2-(dimethylcarbamoyl)isonicotinic acid (CAS 1243375-50-9)
- Valganciclovir Hydrochloride EP Impurity M (CAS CATO-C4X-177414)
- ([13C6]Leu14)-Glucagon (1-29) (human, rat, porcine) trifluoroacetate salt (CAS 1802078-39-2)
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