Abemaciclib impurity 115 CAS CATO-C4X-2937115
| CAS No. | CATO-C4X-2937115 |
| Molecular Formula | C6H7ClN2 |
| Molecular Weight | 142.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Abemaciclib impurity 115 is closely related to a nitrile group, chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Abemaciclib impurity 115 (CAS CATO-C4X-2937115) is a certified pharmaceutical impurity reference standard with the molecular formula C6H7ClN2 and a molecular weight of 142.59 g/mol.
Abemaciclib impurity 115 (C6H7ClN2) contains a nitrile group, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Abemaciclib impurity 115 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H7ClN2 |
| Molecular Weight | 142.59 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Abemaciclib Standards
- Abemaciclib Impurity 27 (CAS 22462-34-6)
- Abemaciclib Impurity 40 (CAS CATO-C4X-293740)
- Abemaciclib Impurity 24 (CAS CATO-C4X-293724)
- Abemaciclib impurity 116 (CAS CATO-C4X-2937116)
- Abemaciclib impurity 104 (CAS 150807-86-6)
- Abemaciclib Impurity 2 (CAS 1528469-78-4)
- Abemaciclib Impurity 36 (CAS CATO-C4X-293736)
- Abemaciclib Impurity 7 (CAS 414881-11-1)
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