Abemaciclib Impurity 154 CAS CATO-C4X-2937154
| CAS No. | CATO-C4X-2937154 |
| Molecular Formula | C17H25BF2N2O2 |
| Molecular Weight | 338.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 338.20 g/mol gives Abemaciclib Impurity 154 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Abemaciclib Impurity 154 (CAS CATO-C4X-2937154, C17H25BF2N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C17H25BF2N2O2, Abemaciclib Impurity 154 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 338.20 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H25BF2N2O2 |
| Molecular Weight | 338.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Abemaciclib Standards
- Abemaciclib Impurity 77 (CAS CATO-C4X-293777)
- Abemaciclib Impurity 79 (CAS CATO-C4X-293779)
- Abemaciclib Impurity 123 (CAS CATO-C4X-2937123)
- Abemaciclib Impurity 89 (CAS CATO-C4X-293789)
- Abemaciclib Impurity 63 (CAS CATO-C4X-293763)
- Abemaciclib Impurity 125 (CAS CATO-C4X-2937125)
- Abemaciclib Impurity 126 (CAS CATO-C4X-2937126)
- Abemaciclib Impurity 170 (CAS CATO-C4X-2937170)
Recommended Standards
- Lisinopril Impurity 11 (CAS CATO-C4X-168111)
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- tert-Butyl (7-bromo-2-methylquinazolin-4-yl)carbamate (CAS 2680781-27-3)
- Methylprednisolone Impurity 1 (CAS CATO-C4X-19191)
- Roxatidine Impurity 24 (CAS CATO-C4X-121324)
- Ibuprofen EP Impurity I (CAS 2143535-26-4)
- L-Glufosinate (CAS 35597-44-5)
- Ethyl (S)-3-hydroxypentanoate (CAS 73143-67-6)
- 3-(4-Chlorophenyl)-2,6-dimethylpropiophenone (CAS 898788-03-9)
- 4-CHLORO-2-(3-FLUOROPYRIDIN-2-YL)-5-ISOPROPYLPYRIMIDINE (CAS 1801335-68-1)
- (S)-2-Hydroxy-2-phenylethyl 4-methylbenzenesulfonate (CAS 40435-14-1)
- Moxifloxacin Impurity 10 (CAS 172602-83-4)
- D-Ala18-Tirzepatide (CAS CATO-CPTD788916)
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