Abemaciclib Impurity 123 CAS CATO-C4X-2937123
| CAS No. | CATO-C4X-2937123 |
| Molecular Formula | C16H19ClFN5 |
| Molecular Weight | 335.81 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Abemaciclib Impurity 123 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Abemaciclib Impurity 123 (CAS CATO-C4X-2937123) is a certified pharmaceutical impurity reference standard with the molecular formula C16H19ClFN5 and a molecular weight of 335.81 g/mol.
Abemaciclib Impurity 123 (C16H19ClFN5) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H19ClFN5 |
| Molecular Weight | 335.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Abemaciclib Standards
- Abemaciclib Impurity 154 (CAS CATO-C4X-2937154)
- Abemaciclib Impurity 77 (CAS CATO-C4X-293777)
- Abemaciclib Impurity 79 (CAS CATO-C4X-293779)
- Abemaciclib Impurity 63 (CAS CATO-C4X-293763)
- Abemaciclib Impurity 89 (CAS CATO-C4X-293789)
- Abemaciclib Impurity N1 (CAS 2177297-46-8)
- Abemaciclib Impurity N3 (CAS 1231930-42-9)
- Abemaciclib Impurity 4 (CAS CATO-C4X-29374)
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