Abemaciclib Impurity 166 CAS CATO-C4X-2937166
| CAS No. | CATO-C4X-2937166 |
| Molecular Formula | C25H30F2N8 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Abemaciclib Impurity 166 (CAS CATO-C4X-2937166), a pharmacopoeial impurity reference standard (molecular formula C25H30F2N8HCl, MW 517.02 g/mol) used for the identification and quantification of trace impurities in APIs.
Abemaciclib Impurity 166 (C25H30F2N8HCl) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H30F2N8 HCl |
| Molecular Weight | 517.02 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 8 |
Related Abemaciclib Standards
- Abemaciclib Impurity N5 (CAS 1038408-36-4)
- Abemaciclib Impurity 21 (CAS 1178566-47-6 (free base))
- Abemaciclib (CAS 1231929-97-7)
- Abemaciclib Impurity N2 (CAS 1231930-29-2)
- Abemaciclib Impurity N4 (CAS 1231930-33-8)
- Abemaciclib Impurity N7 (CAS 1231930-37-2)
- Abemaciclib Impurity N3 (CAS 1231930-42-9)
- Abemaciclib Impurity 70 (CAS 1231930-47-4)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com