Ivacaftor-d4 CAS CATO-C4X-296421
| CAS No. | CATO-C4X-296421 |
| Molecular Formula | - |
| Molecular Weight | 396.52 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Ivacaftor-d4 (CAS CATO-C4X-296421) is a high-purity analytical reference standard with the molecular formula C24H24D4N2O3 and a molecular weight of 396.52 g/mol.
The molecular framework of Ivacaftor-d4 (C24H24D4N2O3) is characterized by deuterium isotope labeling, a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Ivacaftor-d4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H24D4N2O3 |
| Molecular Weight | 396.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | ＞95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 2 |
Related Ivacaftor Standards
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- Ivacaftor-d9 (CAS 1413431-07-8)
- Ivacaftor Carboxylic Acid Lactone (CAS 1246213-41-1)
- Ivacaftor impurity 16 (CAS CATO-C4X-296416)
- Ivacaftor impurity 19 (CAS CATO-C4X-296419)
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