Acalabrutinib Impurity 3 CAS CATO-C4X-30553
| CAS No. | CATO-C4X-30553 |
| Molecular Formula | C18H18BrN5O2 |
| Molecular Weight | 416.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Acalabrutinib Impurity 3 (CAS CATO-C4X-30553) is a certified pharmaceutical impurity reference standard with the molecular formula C18H18BrN5O2 and a molecular weight of 416.27 g/mol.
Structurally, Acalabrutinib Impurity 3 (C18H18BrN5O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 416.27 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C18H18BrN5O2 |
| Molecular Weight | 416.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 5 |
Related Acalabrutinib Standards
- Acalabrutinib Impurity 2 (CAS CATO-C4X-30552)
- Acalabrutinib Impurity 4 (CAS 2198380-46-8)
- Acalabrutinib Impurity 16 (CAS 2230757-50-1)
- Acalabrutinib Impurity 13 (CAS CATO-C4X-305513)
- Acalabrutinib Impurity 12 (CAS CATO-C4X-305512)
- Acalabrutinib Impurity 10 (CAS CATO-C4X-305510)
- Acalabrutinib Impurity 15 (CAS CATO-C4X-305515)
- Acalabrutinib Impurity 18 (CAS CATO-C4X-305518)
Recommended Standards
- Methyl 5-bromo-4-(N-methanesulfonylmethanesulfonamido)-2-methoxybenzoate (CAS 860785-04-2)
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- Butyl 1-bromo-4-hydroxy-7-phenoxyisoquinoline-3-carboxylate (CAS 808115-53-9)
- (E)-({6-phenylimidazo[2,1-b][1,3]thiazol-5-yl}methylidene)amino 3,4-dichlorobenzoate (CAS 338404-86-7)
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- Polymyxin Impurity 23 (CAS CATO-C4X-225523)
- Finerenone Impurity 36 (CAS 2087452-81-9)
- Fibroblast Growth Factors (CAS 62031-54-3)
- 3-[2-(Dimethylamino)ethyl]-5-methylimidazolidin-4-one (CAS 1501593-74-3)
- methyl 4-fluoro-2-oxo-3H-1,3-benzoxazole-5-carboxylate (CAS 2387598-80-1)
- 5-[[9-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-9H-xanthen-3-yl]oxy]pentanoic Acid (CAS 168897-70-9)
- azocane-1-sulfonamide (CAS 29609-21-0)
- Ethyl 2-fluoroacetimidate hydrochloride (CAS 3862-78-0)
- Semaglutide Impurity 123 (CAS 71997-93-8)
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