Acalabrutinib Impurity 29 CAS CATO-C4X-305529
| CAS No. | CATO-C4X-305529 |
| Molecular Formula | C10H10ClN5O |
| Molecular Weight | 251.67 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Acalabrutinib Impurity 29 (C10H10ClN5O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 251.67 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Acalabrutinib Impurity 29 (CAS CATO-C4X-305529, C10H10ClN5O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H10ClN5O |
| Molecular Weight | 251.67 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Acalabrutinib Standards
- Acalabrutinib Impurity 25 (CAS CATO-C4X-305525)
- Acalabrutinib Impurity 6 (CAS CATO-C4X-30556)
- Acalabrutinib Impurity 7 (CAS CATO-C4X-30557)
- Acalabrutinib Impurity 9 (CAS CATO-C4X-30559)
- Acalabrutinib Impurity 8 (CAS CATO-C4X-30558)
- Acalabrutinib Impurity 11 (CAS CATO-C4X-305511)
- Acalabrutinib Impurity 30 (CAS CATO-C4X-305530)
- Acalabrutinib Impurity 24 (CAS 2097352-14-0)
Recommended Standards
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