Teriflunomide impurity 1 CAS CATO-C4X-31201
| CAS No. | CATO-C4X-31201 |
| Molecular Formula | C12H8F3N3O3 |
| Molecular Weight | 299.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Teriflunomide impurity 1 (CAS CATO-C4X-31201) is a certified pharmaceutical impurity reference standard with the molecular formula C12H8F3N3O3 and a molecular weight of 299.21 g/mol.
Teriflunomide impurity 1 (C12H8F3N3O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H8F3N3O3 |
| Molecular Weight | 299.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Teriflunomide Standards
- Teriflunomide impurity 2 (CAS CATO-C4X-31202)
- Teriflunomide Impurity C53 (CAS 1011244-72-6)
- (E)-Teriflunomide (CAS 214782-56-6)
- Teriflunomide Impurity 5 (CAS 220512-86-7)
- Teriflunomide Impurity 6 (CAS 62004-05-1)
- Teriflunomide Impurity 2 (CAS 69066-42-8)
- Teriflunomide Impurity 7 (CAS 854677-43-3)
- Teriflunomide Impurity 4 (CAS CATO-C4X-31204)
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