Orforglipron impurity 126 CAS CATO-C4X-3234126
| CAS No. | CATO-C4X-3234126 |
| Molecular Formula | C24H35FN4O2 |
| Molecular Weight | 430.56 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 430.56 g/mol gives Orforglipron impurity 126 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Orforglipron impurity 126 (CAS CATO-C4X-3234126, C24H35FN4O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Orforglipron impurity 126 (C24H35FN4O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Orforglipron impurity 126 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H35FN4O2 |
| Molecular Weight | 430.56 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Orforglipron Standards
- Orforglipron impurity 32 (CAS CATO-C4X-323432)
- Orforglipron Impurity 13 (CAS 2212021-61-7)
- Orforglipron Impurity 17 (CAS CATO-C4X-323417)
- Orforglipron Impurity 12 (CAS 2212021-81-1)
- Orforglipron impurity 123 (CAS CATO-C4X-3234123)
- Orforglipron impurity 124 (CAS CATO-C4X-3234124)
- Orforglipron impurity 69 (CAS CATO-C4X-323469)
- Orforglipron impurity 75 (CAS CATO-C4X-323475)
Recommended Standards
- Citalopram Impurity 21 (CAS 1433278-32-0)
- Fluorescent Brightener 184 (CAS 7128-64-5)
- Methyl 2-(4-(tert-butyl)benzamido)-5-(diethylcarbamoyl)-4-methylthiophene-3-carboxylate (CAS 424809-80-3)
- Darifenacin D4 (CAS 1095598-84-7)
- Tofacitinib Impurity 242 (CAS CATO-C4X-1079242)
- Pranoprofen Impurity 25 (CAS CATO-C4X-181125)
- Trametinib Impurity N9 (CAS 871700-41-3)
- 2-Bromo-3-(trifluoromethoxy)benzoic acid (CAS 1159512-46-5)
- (R)-4-((4-benzylpiperazin-2-yl)methyl)phenol (CAS 947271-93-4)
- 1-(2,4-Difluorobenzyl)thiourea (CAS 296277-26-4)
- 2-(carboxymethyl)thiophene-3-carboxylic acid (CAS 332013-53-3)
- Dimethyl 1-(3,5-dimethoxyphenyl)-1H-1,2,3-triazole-4,5-dicarboxylate (CAS 895641-56-2)
- N-cyclopropyl-3,4-difluorobenzenesulfonamide (CAS 726149-96-8)
- (Asn5)-Delta-Sleep Inducing Peptide (H-2555.0005) (CAS 80064-67-1)
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