Trametinib Impurity N9 CAS 871700-41-3
| CAS No. | 871700-41-3 |
| Molecular Formula | C12H11FIN3O2 |
| Molecular Weight | 375.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Trametinib Impurity N9 (CAS 871700-41-3, C12H11FIN3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C12H11FIN3O2, Trametinib Impurity N9 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/iodine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 375.14 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Trametinib Impurity N9 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H11FIN3O2 |
| Molecular Weight | 375.14 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/I-containing |
| Nitrogen Atoms | 3 |
Related Trametinib Standards
- Trametinib Impurity 1 (CAS 871700-28-6)
- Trametinib impurity 8 (CAS 871700-26-4)
- Trametinib impurity 11 (CAS CATO-C4X-278211)
- Trametinib impurity 7 (CAS 871700-22-0)
- Trametinib Impurity N1 (CAS 329941-39-1)
- Trametinib impurity 12 (CAS 3018911-27-5)
- Trametinib impurity 03 (CAS 871700-24-2)
- Trametinib Impurity 16 (CAS CATO-C4X-278216)
Recommended Standards
- 5-Bromo-2-{[2-methyl-3-(trifluoromethyl)phenyl]amino}nicotinic acid (CAS 75369-60-7)
- 2-[(4-Iodoanilino)methylene]-1H-indene-1,3(2H)-dione (CAS 1020251-90-4)
- Ethyl 5-amino-1-(4-fluorophenyl)-4-iodo-1H-pyrazole-3-carboxylate (CAS 1427011-65-1)
- 6-Bromo-5-fluoro-1-(2-(trifluoromethyl)phenyl)-2,3-dihydro-1H-inden-1-ol (CAS 1830164-33-4)
- Ampicillin Impurity 40 (CAS CATO-C4X-144340)
- Minoxidil Impurity 60 (CAS CATO-C4X-170060)
- Mesalazine Impurity 50 (CAS CATO-C4X-132450)
- 7-tert-butyl 3-ethyl 8,9-dihydro-5H-imidazo[1,2-d][1,4]diazepine-3,7(6H)-dicarboxylate (CAS 1341037-28-2)
- Brivaracetam Impurity 2 (CAS 357336-19-7)
- 4-Chloro-2-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide (CAS 796032-92-3)
- 4-Methoxy-3-propylisobenzofuran-1(3H)-one (CAS 88440-79-3)
- 2,3-Dimethyl-3-pyrrolidinomethyl benzophenone (CAS 898770-34-8)
- 4-Bromo-1-ethyl-3,5-dimethyl-1h-pyrazole (CAS 51108-51-1)
- Semaglutide Impurity 151 xTFA (CAS CATO-C4X-2226151)
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