Encorafenib Impurity 16 CAS CATO-C4X-324916
| CAS No. | CATO-C4X-324916 |
| Molecular Formula | C19H29IN8O3 |
| Molecular Weight | 544.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Encorafenib Impurity 16 (CAS CATO-C4X-324916) is a certified pharmaceutical impurity reference standard with the molecular formula C19H29IN8O3 and a molecular weight of 544.39 g/mol.
Based on its molecular formula C19H29IN8O3, Encorafenib Impurity 16 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, iodine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 544.39 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C19H29IN8O3 |
| Molecular Weight | 544.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | I-containing |
| Nitrogen Atoms | 8 |
Related Encorafenib Standards
- Encorafenib (CAS 1269440-17-6)
- Encorafenib Impurity 17 (CAS CATO-C4X-324917)
- Encorafenib Impurity 2 (CAS 1269440-29-0)
- Encorafenib Impurity 5 (CAS CATO-C4X-32495)
- Encorafenib Impurity 12 (CAS CATO-C4X-324912)
- Encorafenib Impurity 4 (CAS CATO-C4X-32494)
- Encorafenib Impurity 3 (CAS CATO-C4X-32493)
- Encorafenib Impurity 11 (CAS CATO-C4X-32411)
Recommended Standards
- N-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine-1-carbonothioyl)-3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamide (CAS 303150-16-5)
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- (E)-[(5-{[(4-tert-butylphenyl)methyl]sulfanyl}-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methylidene]amino 2,4-dichlorobenzoate (CAS 318239-34-8)
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- Custom peptides (CAS CATO-CPTD788509)
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