Lotilaner Impurity 6 CAS CATO-C4X-32566
| CAS No. | CATO-C4X-32566 |
| Molecular Formula | C17H11Cl3F3NO3S |
| Molecular Weight | 472.69 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Lotilaner Impurity 6.
As a process- or degradation-related impurity, Lotilaner Impurity 6 (CAS CATO-C4X-32566, C17H11Cl3F3NO3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Lotilaner Impurity 6 (C17H11Cl3F3NO3S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H11Cl3F3NO3S |
| Molecular Weight | 472.69 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Lotilaner Standards
- Lotilaner Impurity 26 (CAS 2758907-90-1)
- Lotilaner Impurity 3 (CAS CATO-C4X-32563)
- Lotilaner Impurity 19 (CAS CATO-C4X-325619)
- Lotilaner Impurity 9 (CAS CATO-C4X-32569)
- Lotilaner Impurity 16 (CAS CATO-C4X-325616)
- Lotilaner Impurity 5 (CAS 1613733-72-4)
- Lotilaner Impurity 13 (CAS CATO-C4X-325613)
- Lotilaner Impurity 2 (CAS CATO-C4X-32562)
Recommended Standards
- 102919-76-6 GKB52TAX5N Scutellaric acid 3alpha,24-Dihydroxyolean-12-en-28-oic acid UNII-GKB52TAX5N (CAS 102919-76-6)
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- Ganodermanontriol (CAS 106518-63-2)
- Tipiracil Impurity 4 (CAS CATO-C4X-10054)
- Dolutegravir Impurity 43 (CAS 2651309-06-5)
- Imiquimod Impurity N3 (CAS 935521-01-0)
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- 5,6-Di(thiophen-2-yl)-1,2,4-triazin-3-ol (CAS 726154-49-0)
- 1-(3,4-Difluorobenzyl)pyrrolidin-3-ol (CAS 864414-83-5)
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- 2-Methylbenzofuran-4-carbonitrile (CAS 515163-40-3)
- D-[Phe]6-Liraglutide (CAS CATO-C4X-199235)
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