Lotilaner Impurity 16 CAS CATO-C4X-325616
| CAS No. | CATO-C4X-325616 |
| Molecular Formula | C17H12Cl3F3O4S |
| Molecular Weight | 475.69 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Lotilaner Impurity 16 (CAS CATO-C4X-325616), a pharmacopoeial impurity reference standard (molecular formula C17H12Cl3F3O4S, MW 475.69 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Lotilaner Impurity 16 (C17H12Cl3F3O4S) is characterized by a flavonoid core, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C17H12Cl3F3O4S |
| Molecular Weight | 475.69 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Sulfur Atoms | 1 |
Related Lotilaner Standards
- Lotilaner Impurity 9 (CAS CATO-C4X-32569)
- Lotilaner Impurity 5 (CAS 1613733-72-4)
- Lotilaner Impurity 26 (CAS 2758907-90-1)
- Lotilaner Impurity 3 (CAS CATO-C4X-32563)
- Lotilaner Impurity 6 (CAS CATO-C4X-32566)
- Lotilaner Impurity 19 (CAS CATO-C4X-325619)
- Lotilaner Impurity 13 (CAS CATO-C4X-325613)
- Lotilaner Impurity 2 (CAS CATO-C4X-32562)
Recommended Standards
- 5-Chloro-N-(3,5-dichlorophenyl)-2-oxo-1-(3-(trifluoromethyl)benzyl)-1,2-dihydropyridine-3-carboxamide (CAS 338977-53-0)
- 2-(N-(2-chloro-5-(trifluoromethyl)phenyl)methylsulfonamido)-N-(2,4-dichlorophenyl)acetamide (CAS 339018-84-7)
- 5-Chloro-N-(2,3-dichlorophenyl)-2-oxo-1-(4-(trifluoromethyl)benzyl)-1,2-dihydropyridine-3-carboxamide (CAS 338977-89-2)
- 1-(Octadecylamino)anthracene-9,10-dione (CAS 29957-05-9)
- Vonoprazan Impurity 247 (CAS CATO-C4X-1020247)
- Ibrutinib Impurity 74 (CAS 2554619-82-6)
- Ribavirin EP Impurity A (CAS 39925-19-4)
- Ethyl 2-azabicyclo[2.2.2]oct-5-ene-2-carboxylate (CAS 3693-69-4)
- 5-(4-Methoxybenzyl)-2-phenylpyrimidine-4,6-diamine (CAS 163590-00-9)
- 5H-Cyclopenta[c]pyridine-5,7(6H)-dione (CAS 5807-19-2)
- 3-Bromopyridine-2,5-diamine (CAS 896160-69-3)
- tert-Butyl 3-cyano-4-hydroxypyrrolidine-1-carboxylate (CAS 197143-33-2)
- 1-Methyl-7-phenylquinolin-2(1H)-one (CAS 14788-54-6)
- D-Glu3-Tirzepatide (CAS CATO-CPTD788927)
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