Glumetinib Impurity 6 CAS CATO-C4X-32596
| CAS No. | CATO-C4X-32596 |
| Molecular Formula | C13H8BrN5O2S |
| Molecular Weight | 378.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Glumetinib Impurity 6 (CAS CATO-C4X-32596, C13H8BrN5O2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, bromine substitution, Glumetinib Impurity 6 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 378.20 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Glumetinib Impurity 6 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H8BrN5O2S |
| Molecular Weight | 378.20 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Glumetinib Standards
- Glumetinib Impurity 5 (CAS CATO-C4X-32595)
- Glumetinib Impurity 15 (CAS CATO-C4X-325915)
- Glumetinib Impurity 7 (CAS CATO-C4X-32597)
- Glumetinib Impurity 4 (CAS CATO-C4X-32594)
- Glumetinib impurity 1 (CAS CATO-C4X-32591)
- Glumetinib Impurity 2 (CAS CATO-C4X-32592)
- Glumetinib Impurity 3 (CAS CATO-C4X-32593)
- Glumetinib (CAS 1642581-63-2)
Recommended Standards
- 2-Chloro-N-[6-chloro-3-(3-methoxyphenyl)-4-oxo-4H-chromen-2-yl]acetamide (CAS 1017420-48-2)
- Morpholinomethanol (CAS 4432-43-3)
- Ethyl 2-({[2-(2,4-dichlorophenoxy)propanehydrazido]carbonyl}amino)acetate (CAS 1023488-72-3)
- Diethyl 2-(1-(2,4-dichlorophenyl)-2-nitroethyl)malonate (CAS 866152-99-0)
- Benvitimod impurity 8 (CAS 91764-23-7)
- Urapidil Impurity 62 HCl (CAS CATO-C4X-192462)
- Pioglitazone Impurity 20 (CAS 69603-36-7)
- 5-(((4-Chlorophenyl)thio)methyl)-N-hydroxyisoxazole-3-carboxamide (CAS 823220-04-8)
- 2-Chloro-4-fluoro-3-methylbenzonitrile (CAS 796600-15-2)
- 4-[2-(Methylsulfanyl)phenyl]-N-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)piperazine-1-carboxamide (CAS 866137-35-1)
- 2-Methyl-2-pyridylaminoethanol (CAS 122321-04-4)
- Paliperidone Impurity 53 (CAS CATO-C4X-172453)
- 1'-Ethyl-1H,1'H-3,4'-bipyrazole (CAS 1006320-10-0)
- C-Peptide (human) (CAS 33017-11-7)
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