Glumetinib Impurity 5 CAS CATO-C4X-32595
| CAS No. | CATO-C4X-32595 |
| Molecular Formula | C13H8BrN5O2S |
| Molecular Weight | 378.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Glumetinib Impurity 5.
As a process- or degradation-related impurity, Glumetinib Impurity 5 (CAS CATO-C4X-32595, C13H8BrN5O2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Glumetinib Impurity 5 (C13H8BrN5O2S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Glumetinib Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H8BrN5O2S |
| Molecular Weight | 378.20 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Glumetinib Standards
- Glumetinib Impurity 6 (CAS CATO-C4X-32596)
- Glumetinib Impurity 15 (CAS CATO-C4X-325915)
- Glumetinib Impurity 7 (CAS CATO-C4X-32597)
- Glumetinib Impurity 4 (CAS CATO-C4X-32594)
- Glumetinib impurity 1 (CAS CATO-C4X-32591)
- Glumetinib Impurity 2 (CAS CATO-C4X-32592)
- Glumetinib Impurity 3 (CAS CATO-C4X-32593)
- Glumetinib (CAS 1642581-63-2)
Recommended Standards
- Morpholinomethanol (CAS 4432-43-3)
- Diethyl 2-(1-(2,4-dichlorophenyl)-2-nitroethyl)malonate (CAS 866152-99-0)
- 2-Chloro-N-[6-chloro-3-(3-methoxyphenyl)-4-oxo-4H-chromen-2-yl]acetamide (CAS 1017420-48-2)
- {[(2R,3S,5R)-5-[2,4-dioxo-5-(trifluoromethyl)-1,2,3,4-tetrahydropyrimidin-1-yl]-3-hydroxyoxolan-2-yl]methoxy}phosphonic acid (CAS 345-02-8)
- Lomefloxacin Impurity 18 (CAS CATO-C4X-207318)
- Pramipexole Impurity 12 (CAS 2245708-68-1)
- Iguratimod Impurity 6 (CAS 123664-84-6)
- cis-Dichlorobis(triphenylphosphite)platinum(II) (CAS 30053-58-8)
- 8-Chloro-5,6-dihydrobenzo[f]pyrido[2,3-b][1,4]oxazepine (CAS 1708370-77-7)
- 4-(2-Amino-4-methylphenyl)-2-piperazinone (CAS 1097785-67-5)
- Terbutaline Impurity 6 (CAS 52144-90-8)
- 4-(1H-Indol-3-yl)-2-methylbut-3-yn-2-ol (CAS 62365-80-4)
- N-(4-Fluoro-3-nitrophenyl)aminosulfonamide (CAS 1708053-62-6)
- Semaglutide Impurity 149 (CAS CATO-C4X-2226149)
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