Atogepant Impurity 4 CAS CATO-C4X-32854
| CAS No. | CATO-C4X-32854 |
| Molecular Formula | C22H23F3N2O2 |
| Molecular Weight | 404.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Atogepant Impurity 4 (C22H23F3N2O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Atogepant Impurity 4 (CAS CATO-C4X-32854) is a certified pharmaceutical impurity reference standard with the molecular formula C22H23F3N2O2 and a molecular weight of 404.43 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Atogepant Impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H23F3N2O2 |
| Molecular Weight | 404.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Atogepant Standards
- Atogepant Impurity 28 (CAS 957122-46-2)
- Atogepant Impurity 78 (CAS 1488326-89-1)
- Atogepant Impurity 73 (CAS CATO-C4X-328573)
- Atogepant Impurity 21 (CAS 1375542-65-6)
- Atogepant Impurity 27 (CAS 957122-47-3)
- Atogepant Impurity 17 (CAS CATO-C4X-328517)
- Atogepant Impurity 12 (CAS CATO-C4X-328512)
- Atogepant Impurity 18 (CAS CATO-C4X-328518)
Recommended Standards
- Riociguat EP Impurity B (CAS 3052969-92-0)
- 4'-fluoro-5-hydroxy-4-(1,2,3,4-tetrahydroisoquinolin-1-yl)-6-(1H-1,2,4-triazol-1-yl)-1,6-dihydro-[1,1'-biphenyl]-3(2H)-one (CAS 1005106-96-6)
- N-tert-Butyl-2-[3-(trifluoromethyl)benzoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (CAS 318256-36-9)
- Ceftibuten Impurity 1 (CAS 103054-27-9)
- Gemcitabine Impurity 9 (CAS 143157-22-6)
- Bosentan Impurity 19 (CAS CATO-C4X-156419)
- Mirabegron Impurity 115 (CAS CATO-C4X-1032115)
- 7-Amino-1,3-dihydrobenzo[c]isothiazole 2,2-dioxide (CAS 232599-76-7)
- 9-Cyclopropyl-6-fluoro-8-methoxy-7-(2-methylpyridin-4-yl)isothiazolo[5,4-b]quinoline-3,4(2H,9H)-dione (CAS 906527-41-1)
- Ethyl 11-bromoundecanoate (CAS 6271-23-4)
- 3-(Naphthalen-1-yl)acrylic acid (CAS 13026-12-5)
- 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-inden-5-ol (CAS 133-21-1)
- 9-[3-(4-Bromo-1H-pyrazol-1-yl)propyl]-9H-purin-6-amine (CAS 1499402-58-2)
- Semaglutide impurity 30 (CAS CATO-C4X-222630)
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