Riociguat EP Impurity B CAS 3052969-92-0
| CAS No. | 3052969-92-0 |
| Molecular Formula | C20H20N8O2 |
| Molecular Weight | 404.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Riociguat EP Impurity B.
Riociguat EP Impurity B (CAS 3052969-92-0) is a certified pharmaceutical impurity reference standard with the molecular formula C20H20N8O2 and a molecular weight of 404.43 g/mol.
Structurally, Riociguat EP Impurity B (C20H20N8O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 404.43 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Riociguat EP Impurity B under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H20N8O2 |
| Molecular Weight | 404.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2005 |
| Nitrogen Atoms | 8 |
Related Riociguat Standards
- Riociguat Impurity 18 (CAS 1361569-23-4)
- Riociguat Impurity 41 (CAS CATO-C4X-174941)
- Riociguat Impurity 36 (CAS CATO-C4X-174936)
- Riociguat EP Impurity A (CAS 625115-52-8)
- Riociguat impurity 27 (CAS CATO-C4X-174927)
- Riociguat Impurity 21 (CAS CATO-C4X-174921)
- Riociguat Impurity 16 (CAS 1361569-18-7)
- Riociguat Impurity 11 (CAS CATO-C4X-174911)
Recommended Standards
- N-tert-Butyl-2-[3-(trifluoromethyl)benzoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (CAS 318256-36-9)
- Atogepant Impurity 4 (CAS CATO-C4X-32854)
- N-phenyl-3-(thiophen-2-yl)-6-(trifluoromethyl)thieno[3,2-b]pyridine-2-carboxamide (CAS 477845-15-1)
- 4'-fluoro-5-hydroxy-4-(1,2,3,4-tetrahydroisoquinolin-1-yl)-6-(1H-1,2,4-triazol-1-yl)-1,6-dihydro-[1,1'-biphenyl]-3(2H)-one (CAS 1005106-96-6)
- Tadalafil Impurity 173 (CAS CATO-C4X-1087173)
- Bumetanide Impurity 83 (CAS CATO-C4X-198683)
- ent-Cefradine EP Impurity B (CAS 26108-29-2)
- (S)-2-Isopropyl-1,2,3,4-tetrahydroquinoline (CAS 608525-30-0)
- 6-Bromo-4-(difluoromethyl)-5-iodopicolinic acid (CAS 1805170-57-3)
- 3-vinyloxetane (CAS 33879-62-8)
- 2,2-Diethoxy-N,N-dimethylethan-1-amine (CAS 3616-56-6)
- Rocuronium Impurity 35 (CAS CATO-C4X-124235)
- 5-((tert-Butoxycarbonyl)(methyl)amino)pentanoic acid (CAS 124073-08-1)
- Semaglutide impurity 91 (CAS CATO-C4X-222691)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com