Samidorphan Impurity 8 CAS CATO-C4X-33098
| CAS No. | CATO-C4X-33098 |
| Molecular Formula | C21H24F3NO6S |
| Molecular Weight | 475.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Samidorphan Impurity 8 (CAS CATO-C4X-33098) is a certified pharmaceutical impurity reference standard with the molecular formula C21H24F3NO6S and a molecular weight of 475.48 g/mol.
Samidorphan Impurity 8 (C21H24F3NO6S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H24F3NO6S |
| Molecular Weight | 475.48 g/mol |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Samidorphan Standards
- Samidorphan impurity 1 (CAS 361525-83-9)
- Samidorphan Impurity 3 (CAS CATO-C4X-33093)
- Samidorphan Impurity 12 (CAS CATO-C4X-330912)
- Samidorphan (CAS 852626-89-2)
- Samidorphan Impurity 10 (CAS 886588-56-3)
- Samidorphan (CAS 421552-35-4)
- Samidorphan Impurity 11 (CAS 886588-57-4)
- Samidorphan Impurity 4 (CAS CATO-C4X-33094)
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