Nerandomilast impurity 3 CAS CATO-C4X-34733
| CAS No. | CATO-C4X-34733 |
| Molecular Formula | C10H14ClN3 |
| Molecular Weight | 211.69 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Nerandomilast impurity 3 (C10H14ClN3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Nerandomilast impurity 3 (CAS CATO-C4X-34733) is a certified pharmaceutical impurity reference standard with the molecular formula C10H14ClN3 and a molecular weight of 211.69 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nerandomilast impurity 3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H14ClN3 |
| Molecular Weight | 211.69 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Nerandomilast Standards
- Nerandomilast impurity 15 (CAS CATO-C4X-347315)
- Nerandomilast impurity 20 (CAS CATO-C4X-347320)
- Nerandomilast impurity 4 (CAS CATO-C4X-34734)
- Nerandomilast impurity 6 (CAS CATO-C4X-34736)
- Nerandomilast impurity 27 (CAS CATO-C4X-347327)
- Nerandomilast impurity 32 (CAS CATO-C4X-347332)
- Nerandomilast impurity 17 (CAS CATO-C4X-347317)
- Nerandomilast impurity 18 (CAS CATO-C4X-347318)
Recommended Standards
- Tolvaptan Impurity 78 (CAS 1863916-82-8)
- 2-Ethyl-6-Methyl-2-Chloroacetanilide (CAS 32428-71-0)
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- Propachlor (CAS 1918-16-7)
- Salmeterol Impurity 28 (CAS CATO-C4X-105028)
- 7-AVCA Impurity 1 (CAS CATO-C4X-23161)
- Atrasentan Impurity 112 (CAS 1059754-98-1)
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- Tetrabutylammonium bromide xhydrate (CAS 37451-67-5)
- 3-(Butoxymethyl)heptane (CAS 62625-25-6)
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- Butyl 2-((2,6-dimethylphenyl)carbamoyl)piperidine-1-carboxylate (CAS 2488656-58-0)
- 4-Nitro-1-(phenoxymethyl)-1H-pyrazole-3-carboxylic acid (CAS 1006436-95-8)
- Allo-Thr5-Tirzepatide (CAS CATO-CPTD788934)
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