Nerandomilast impurity 20 CAS CATO-C4X-347320
| CAS No. | CATO-C4X-347320 |
| Molecular Formula | C6H4Cl2N2OS |
| Molecular Weight | 223.08 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 223.08 g/mol gives Nerandomilast impurity 20 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Nerandomilast impurity 20 (CAS CATO-C4X-347320) is a certified pharmaceutical impurity reference standard with the molecular formula C6H4Cl2N2OS and a molecular weight of 223.08 g/mol.
Owing to an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Nerandomilast impurity 20 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 223.08 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H4Cl2N2OS |
| Molecular Weight | 223.08 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Nerandomilast Standards
- Nerandomilast impurity 4 (CAS CATO-C4X-34734)
- Nerandomilast impurity 6 (CAS CATO-C4X-34736)
- Nerandomilast impurity 15 (CAS CATO-C4X-347315)
- Nerandomilast impurity 3 (CAS CATO-C4X-34733)
- Nerandomilast impurity 17 (CAS CATO-C4X-347317)
- Nerandomilast impurity 27 (CAS CATO-C4X-347327)
- Nerandomilast impurity 32 (CAS CATO-C4X-347332)
- Nerandomilast impurity 18 (CAS CATO-C4X-347318)
Recommended Standards
- Ticagrelor Impurity 123 (CAS 33097-11-9)
- 7-bromo-4-fluoro-1H-indazole (CAS 1000341-72-9)
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- 4-bromo-7-fluoro-1H-pyrrolo[3,2-c]pyridine (CAS 1082040-86-5)
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- Cefpodoxime Impurity 57 (CAS CATO-C4X-157957)
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- 2-(2,6-Dimethoxyphenyl)acetonitrile (CAS 3166-95-8)
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- Rebamipide Impurity 65 (CAS CATO-C4X-152365)
- 2-Amino-5,7-diphenyl-4,7-dihydro-5H-thieno[2,3-c]thiopyran-3-carboxylicacid ethylester (CAS 24895-74-7)
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