Irinotecan Impurity 69 CAS 100286-92-8
| CAS No. | 100286-92-8 |
| Molecular Formula | C25H33N4O8P |
| Molecular Weight | 548.53 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 548.53 g/mol gives Irinotecan Impurity 69 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Irinotecan Impurity 69 (CAS 100286-92-8), a pharmacopoeial impurity reference standard (molecular formula C25H33N4O8P, MW 548.53 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Irinotecan Impurity 69 (C25H33N4O8P) contains a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 11.5, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 548.53 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H33N4O8P |
| Molecular Weight | 548.53 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Nitrogen Atoms | 4 |
Related Irinotecan Standards
- Irinotecan Impurity 34 (CAS 176515-52-9)
- Irinotecan Impurity 30 (CAS CATO-C4X-166730)
- Irinotecan Impurity 28 (CAS CATO-C4X-166728)
- Irinotecan Impurity 29 (CAS CATO-C4X-166729)
- Irinotecan Lactone Impurity (CAS 143490-53-3)
- Irinotecan EP Impurity A (CAS 103816-16-6)
- Irinotecan Impurity 38 (CAS 143490-54-4)
- Irinotecan Impurity 51 (CAS 2944102-98-9)
Recommended Standards
- Flurbiprofen Impurity 157 (CAS CATO-C4X-1444157)
- Icariside I hydrate (CAS 128988-55-6)
- Ethyl 4-cyano-5-(2-((3-cyano-6-(4-fluorophenyl)-4-(trifluoromethyl)pyridin-2-yl)thio)acetamido)-3-methylthiophene-2-carboxylate (CAS 499208-69-4)
- 2,2',7,7'-Tetramethoxy-9,9'-spirobi[fluorene]-3,3',6,6'-tetracarbaldehyde (CAS 1801236-33-8)
- Sumatriptan aminophenyl Impurity C05 (CAS 109903-35-7)
- Molnupiravir Impurity 13 (CAS CATO-C4X-249013)
- Baloxavir Marboxil Impurity 235 (CAS CATO-C4X-2108235)
- 4-(Allyloxy)benzohydrazide (CAS 90480-14-1)
- 4-[5-(Trifluoromethyl)-1H-pyrazol-3-yl]piperidine dihydrochloride (CAS 2103644-61-5)
- 2-Chloro-n-[3-(diethylsulfamoyl)-4-ethoxyphenyl]acetamide (CAS 923773-99-3)
- 3-((3-Fluorobenzyl)thio)-5-(3-methoxy-1-methyl-1H-pyrazol-4-yl)-4-methyl-4H-1,2,4-triazole (CAS 1014072-53-7)
- 1-(4-(1-Methyl-1h-pyrazol-4-yl)phenyl)ethan-1-one (CAS 1178936-51-0)
- Prilocaine EP Impurity A (CAS 19281-31-3)
- Semaglutide impurity 75 (CAS CATO-C4X-222675)
Why CATO?
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