5-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)pyrimidine-2-thiol CAS 1007166-51-9
| CAS No. | 1007166-51-9 |
| Molecular Formula | C10H5ClF3N3S |
| Molecular Weight | 291.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)pyrimidine-2-thiol is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
5-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)pyrimidine-2-thiol (CAS 1007166-51-9), molecular formula C10H5ClF3N3S and molecular weight 291.68 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C10H5ClF3N3S, 5-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)pyrimidine-2-thiol contains a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 291.68 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)pyrimidine-2-thiol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H5ClF3N3S |
| Molecular Weight | 291.68 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 6-Chloro-2-(4,4-difluoropiperidin-1-yl)-4-methyl-3-nitropyridine (CAS 1253378-61-8)
- 4-(3-Chloro-5-trifluoromethyl-pyridin-2-yl)-pyrimidine-2-thiol (CAS 1311278-19-9)
- 3-Chloro-2-(thiophene-2-carbonyl)-5-(trifluoromethyl)pyridine (CAS 338953-29-0)
- 4-Chloro-2-(4-(trifluoromethyl)phenyl)thiazole-5-carbaldehyde (CAS 499796-75-7)
- 5-Chloro-7-(2,4-difluorophenyl)quinolin-8-ol (CAS 648896-48-4)
- 5-Chloro-7-(3,5-difluorophenyl)quinolin-8-ol (CAS 648896-47-3)
- 7-Chloro-N-(2,4-difluorophenyl)quinazolin-4-amine (CAS 477856-24-9)
- 7-Chloro-N-(2,6-difluorophenyl)quinazolin-4-amine (CAS 477856-36-3)
Recommended Standards
- N-[(Chloro(phenoxy)phosphoryl)]-L-Alanine Ethyl Ester (CAS 245078-14-2)
- 2-[4-(2H-Tetrazol-5-yl)phenoxy]-5-chloro-3-fluoropyridine (CAS 1799681-96-1)
- N-(2-Chloroethyl)-N-[4-cyano-3-(trifluoromethyl)phenyl]urea (CAS 1987135-73-8)
- 2-(4-(Trifluoromethyl)phenyl)thiazole-4-carbonyl chloride (CAS 857284-28-7)
- 1-(3-((2-Aminoethyl)(methyl)amino)pyrrolidin-1-yl)ethanone (CAS 1353985-50-8)
- 2-Chloro-4-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (CAS 2121513-87-7)
- 4-bromo-1-(1-phenylethyl)-1H-pyrazole (CAS 1340161-36-5)
- (1R,3S)-3-(4-methoxybenzoyl)cyclohexane-1-carboxylic acid (CAS 735269-73-5)
- Nalmefene Impurity 23 (CAS CATO-C4X-126823)
- 2-(oxolan-2-yl)ethyl methanesulfonate (CAS 133243-93-3)
- Monomethyl Fumarate-D5 (CAS 1616345-45-9)
- 2-Methyl-5-(morpholinosulfonyl)furan-3-carboxylic acid (CAS 306936-37-8)
- Canagliflozin Impurity 106 (CAS CATO-C4X-1123106)
- Semaglutide impurity 72 (CAS CATO-C4X-222672)
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