Tofacitinib Impurity 206 CAS CATO-C4X-1079206
| CAS No. | CATO-C4X-1079206 |
| Molecular Formula | C6H5N3OS |
| Molecular Weight | 167.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tofacitinib Impurity 206.
As a process- or degradation-related impurity, Tofacitinib Impurity 206 (CAS CATO-C4X-1079206, C6H5N3OS) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Tofacitinib Impurity 206 (C6H5N3OS) contains an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 167.19 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H5N3OS |
| Molecular Weight | 167.19 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Tofacitinib Standards
- Tofacitinib Impurity 52 (CAS 694495-63-1)
- Tofacitinib Impurity 140 (CAS CATO-C4X-1079140)
- Tofacitinib Impurity 220 (CAS 1279816-72-6)
- Tofacitinib Impurity 133 (CAS 10132-07-7)
- Tofacitinib Impurity 82 (CAS 1229041-97-7)
- Tofacitinib Impurity 29 (CAS 90953-01-8)
- Tofacitinib Impurity 127 (CAS 1204176-45-3)
- Tofacitinib Impurity 246 (CAS CATO-C4X-1079246)
Recommended Standards
- 2-Thioxo-2,3-dihydro-1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one (CAS 67831-84-9)
- Macitentan Impurity 28 (CAS CATO-C4X-117528)
- Thieno[3,2-b]pyridine-5,7(4H,6H)-dione (CAS 1996670-27-9)
- Famotidine Impurity 81 (CAS CATO-C4X-139281)
- Upadacitinib Impurity 113 (CAS CATO-C4X-2405113)
- Tropisetron Impurity 3 (CAS CATO-C4X-11793)
- Gemcitabine Impurity 11 (CAS 134790-39-9)
- 1-(5-Isopropyl-1h-1,2,4-triazol-3-yl)-2,2-dimethylpropan-1-amine (CAS 1250815-77-0)
- N-(3-Acetylphenyl)-2,2,2-trifluoroacetamide (CAS 56915-87-8)
- N-[(1H-1,2,3-Benzotriazol-1-yl)methyl]-3-chloro-4-fluoroaniline (CAS 297150-27-7)
- O-(3-bromophenyl)hydroxylamine hydrochloride (CAS 1387003-36-2)
- Methyl 4-(bromomethyl)cubane-1-carboxylate (CAS 1350821-99-6)
- 6-Hydroxypyridazine-3-carboxylic acid hydrochloride (CAS 2048273-64-7)
- Glucagon-like peptide 2 (CAS 89750-15-2)
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