Tofacitinib Impurity 52 CAS 694495-63-1
| CAS No. | 694495-63-1 |
| Molecular Formula | C8H10N2O2 |
| Molecular Weight | 166.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tofacitinib Impurity 52.
As a process- or degradation-related impurity, Tofacitinib Impurity 52 (CAS 694495-63-1, C8H10N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Tofacitinib Impurity 52 (C8H10N2O2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Tofacitinib Impurity 52 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H10N2O2 |
| Molecular Weight | 166.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Nitrogen Atoms | 2 |
Related Tofacitinib Standards
- Tofacitinib Impurity 206 (CAS CATO-C4X-1079206)
- Tofacitinib Impurity 133 (CAS 10132-07-7)
- Tofacitinib Impurity 82 (CAS 1229041-97-7)
- Tofacitinib Impurity 140 (CAS CATO-C4X-1079140)
- Tofacitinib Impurity 220 (CAS 1279816-72-6)
- Tofacitinib Impurity 29 (CAS 90953-01-8)
- Tofacitinib Impurity 127 (CAS 1204176-45-3)
- Tofacitinib Impurity 246 (CAS CATO-C4X-1079246)
Recommended Standards
- 4-Methoxy-N-Methyl-2-pyridinecarboxamide (CAS CATO-C4X-104770)
- Dabigatran Impurity 85 (CAS 104961-64-0)
- 4-Methoxy-N-Methyl-2-pyridinecarboxamide (CAS 1878552-33-0)
- Esomeprazole Impurity 97 (CAS 142885-88-9)
- Olodaterol Impurity 10 (CAS CATO-C4X-194310)
- Tadalafil Impurity 145 (CAS 629652-47-7)
- Metoclopramide EP Impurity F HCl (CAS 38059-78-8)
- (4-((3-Methylpiperidin-1-yl)sulfonyl)phenyl)boronic acid (CAS 2096335-51-0)
- 2-(2-Chloroethoxy)phenol (CAS 4792-79-4)
- 2-Cyclopentylbenzofuran-5-carboxylic acid (CAS 1154060-71-5)
- 3-(2-Bromoethyl)benzo[b]thiophene (CAS 19985-73-0)
- 2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidin]-1-one (CAS 159634-65-8)
- Spiro[indoline-3,4'-piperidin]-2-one (CAS 252882-61-4)
- Tirzepatide Impurity 33 (CAS CATO-C4X-324033)
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