Chlortetracycline EP Impurity A HCl CAS 101342-45-4
| CAS No. | 101342-45-4 |
| Molecular Formula | C22H23ClN2O8 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Chlortetracycline EP Impurity A HCl (C22H23ClN2O8HCl) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Chlortetracycline EP Impurity A HCl (CAS 101342-45-4, C22H23ClN2O8HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H23ClN2O8 HCl |
| Molecular Weight | 515.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chlortetracycline Standards
- Chlortetracycline EP Impurity A (CAS 14297-93-9)
- Chlortetracycline hydrochloride (CAS 64-72-2)
- Chlortetracycline EP Impurity H (CAS 7301-38-4)
- Chlortetracycline EP Impurity G (CAS 769895-23-0)
- Chlortetracycline Hydrochloride EP Impurity K (CAS CATO-C4X-233021)
- Chlortetracycline Hydrochloride EP Impurity L (CAS CATO-C4X-233022)
- Chlortetracycline Hydrochloride EP Impurity F (CAS CATO-C4X-233023)
- Chlortetracycline Impurity 24 (CAS CATO-C4X-233024)
Recommended Standards
- Dapagliflozin Impurity 149 (CAS 1616259-14-3)
- Amlodipine Impurity 138 (CAS CATO-C4X-1095138)
- Felodipine EP Impurity A (CAS 96382-71-7)
- 3-Methyl-1-[(pyridin-3-yl)methyl]urea (CAS 36226-41-2)
- 4-(2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)ethyl)aniline (CAS 339012-85-0)
- 4,8-Dichloropyrrolo[1,2-a]quinoxaline (CAS 160657-05-6)
- 4-Fluoro-2-methyl-3-nitrobenzylamine (CAS 1803853-15-7)
- 4-Undecanoyl-1H-pyrrole-2-carboxamide (CAS 251096-63-6)
- 3-(4-Hydroxyphenyl)-5,7-dimethoxy-4H-chromen-4-one (CAS 69127-80-6)
- Tirzepatide Impurity 46 (CAS CATO-C4X-324046)
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