Chlortetracycline EP Impurity A CAS 14297-93-9
| CAS No. | 14297-93-9 |
| Molecular Formula | C22H23ClN2O8 |
| Molecular Weight | 478.88 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Chlortetracycline EP Impurity A is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Chlortetracycline EP Impurity A (CAS 14297-93-9) is a certified pharmaceutical impurity reference standard with the molecular formula C22H23ClN2O8 and a molecular weight of 478.88 g/mol.
Based on its molecular formula C22H23ClN2O8, Chlortetracycline EP Impurity A contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 478.88 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H23ClN2O8 |
| Molecular Weight | 478.88 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chlortetracycline Standards
- Chlortetracycline EP Impurity G (CAS 769895-23-0)
- Chlortetracycline Hydrochloride EP Impurity F (CAS CATO-C4X-233023)
- Chlortetracycline EP Impurity H (CAS 7301-38-4)
- Chlortetracycline Impurity 24 (CAS CATO-C4X-233024)
- Chlortetracycline Hydrochloride EP Impurity K (CAS CATO-C4X-233021)
- Chlortetracycline Hydrochloride EP Impurity L (CAS CATO-C4X-233022)
- Chlortetracycline hydrochloride (CAS 64-72-2)
- Chlortetracycline EP Impurity A HCl (CAS 101342-45-4)
Recommended Standards
- Lenvatinib Impurity 52 (CAS CATO-C4X-114052)
- Aureomycin (CAS 57-62-5)
- 16-Tritriacontanone (CAS 15740-35-9)
- Isochlortetracycline (CAS 514-53-4)
- Fluticasone Impurity 57 (CAS CATO-C4X-165057)
- Tofacitinib Impurity 137 (CAS 7400-06-8)
- Sofosbuvir Impurity 28 (CAS CATO-C4X-105228)
- (5-Methylisoxazol-3-yl)boronic acid (CAS 1373229-27-6)
- Lurasidone Impurity 21 (CAS 188797-79-7)
- (2-Chloro-4-(difluoromethyl)-5-fluoropyridin-3-yl)methanol (CAS 1806978-27-7)
- tert-Butyl 3-benzylazetidine-1-carboxylate (CAS 1714979-63-1)
- 2-Oxo-N-(p-tolyl)oxazolidine-3-sulfonamide (CAS 340185-08-2)
- 5-Amino-1-methyl-1H-indole-2-carboxylic acid (CAS 207845-95-2)
- Semaglutide Impurity 128 (CAS 2490269-78-6)
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