Chlortetracycline EP Impurity G CAS 769895-23-0
| CAS No. | 769895-23-0 |
| Molecular Formula | C22H23ClN2O8 |
| Molecular Weight | 478.88 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Chlortetracycline EP Impurity G (CAS 769895-23-0, C22H23ClN2O8) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Chlortetracycline EP Impurity G (C22H23ClN2O8) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 478.88 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C22H23ClN2O8 |
| Molecular Weight | 478.88 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chlortetracycline Standards
- Chlortetracycline EP Impurity A (CAS 14297-93-9)
- Chlortetracycline Hydrochloride EP Impurity F (CAS CATO-C4X-233023)
- Chlortetracycline EP Impurity H (CAS 7301-38-4)
- Chlortetracycline Impurity 24 (CAS CATO-C4X-233024)
- Chlortetracycline Hydrochloride EP Impurity K (CAS CATO-C4X-233021)
- Chlortetracycline Hydrochloride EP Impurity L (CAS CATO-C4X-233022)
- Chlortetracycline hydrochloride (CAS 64-72-2)
- Chlortetracycline EP Impurity A HCl (CAS 101342-45-4)
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