Tenofovir alafenamide impurity 82 CAS 126771-32-2
| CAS No. | 126771-32-2 |
| Molecular Formula | C13H17NO3 |
| Molecular Weight | 235.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C13H17NO3, Tenofovir alafenamide impurity 82 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 235.28 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Tenofovir alafenamide impurity 82 (CAS 126771-32-2, C13H17NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Tenofovir alafenamide impurity 82 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H17NO3 |
| Molecular Weight | 235.28 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Nitrogen Atoms | 1 |
Related Tenofovir Standards
- Tenofovir alafenamide impurity 79 (CAS 126771-33-3)
- Tenofovir alafenamide impurity 80 (CAS 126771-36-6)
- Tenofovir alafenamide Impurity 79 (CAS 102-10-3)
- Tenofovir Impurity 59 (CAS 116384-56-6)
- Tenofovir alafenamide impurity 85 (CAS 121149-98-2)
- Tenofovir disoproxil Impurity 42 (CAS 1878175-82-6)
- Tenofovir Alafenamide Impurity 26 (CAS CATO-C4X-179726)
- Tenofovir Alafenamide Impurity 47 (CAS 1884329-63-8)
Recommended Standards
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- Prilocaine impurity 46 (CAS CATO-C4X-193446)
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- Josamycin Impurity 6 (CAS CATO-C4X-30156)
- Obeticholic Acid Impurity 14 (CAS CATO-C4X-115314)
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