Clozapine Impurity 14 CAS 1025951-76-1
| CAS No. | 1025951-76-1 |
| Molecular Formula | C20H21ClN4O |
| Molecular Weight | 368.86 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Clozapine Impurity 14 (CAS 1025951-76-1, C20H21ClN4O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Clozapine Impurity 14 (C20H21ClN4O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 368.86 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Clozapine Impurity 14 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H21ClN4O |
| Molecular Weight | 368.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Clozapine Standards
- Clozapine Impurity 15 (CAS 156632-03-0)
- Clozapine EP Impuirty C-D8 N-nitroso (CAS CATO-C4X-134018)
- Clozapine EP Impurity D (CAS 65514-71-8)
- Clozapine N-Oxide (CAS 34233-69-7)
- Clozapine Impurity 22 (CAS CATO-C4X-134022)
- Clozapine-d8 (CAS 1185053-50-2)
- Clozapine-D4 (CAS 204395-52-8)
- Clozapine-D3 (CAS 1215691-72-7)
Recommended Standards
- 9-Chloro-2-(4-methoxyphenyl)-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,1'-cyclopentane] (CAS 303061-30-5)
- Loratadine Impurity 30 (CAS 165740-03-4)
- 2-(4-((5-Chloro-1-methyl-3-phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)pyrimidine (CAS 477714-01-5)
- Paliperidone Impurity 92 (CAS CATO-C4X-172492)
- Busulfan Impurity 17 (CAS CATO-C4X-145517)
- Doxepin Hydrochloride EP Impurity A (CAS 4504-87-4)
- Irbesartan impurity 37 (CAS 1415462-83-7)
- ((Thiazol-2-ylmethyl)carbamoyl)glycine (CAS 1304936-11-5)
- (4-(Methylsulfonyl)pyridin-2-yl)methanamine (CAS 1256802-85-3)
- Cyclopropyl 3-(thiomorpholinomethyl)phenyl ketone (CAS 898788-05-1)
- (5-cyano-1-methyl-1H-pyrrol-2-yl)boronic acid (CAS 860617-71-6)
- (2R,3S,4R,5R)-2-(benzyloxy)-4,5-dihydroxytetrahydro-2H-pyran-3-yl 4-methylbenzenesulfonate (CAS 31079-87-5)
- 4-Cyclopropyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile (CAS 1710292-70-8)
- Semaglutide Impurity 9 (CAS CATO-C4X-22269)
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